The excellent cooperation between the groups of Mihaela Delcea, Uwe Bornscheuer and Michael Lammers enabled to unravel the molecular mechanisms underlying the regulation of the enzyme AMP-forming acetyl-CoA synthetase by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule.

This was achieved by conducting biochemical and structural biological methods, MD-simulations and by applying methods of artificial intelligence performing structure predictions using AlphaFold2. The paper is published in open access format in Nature Communications see here:

C. Qin, L. G. Graf, K. Striska, M. Janetzky, N. Geist, R. Specht, S. Schulze, G. J. Palm, B. Girbardt, B. Dörre, L. Berndt, S. Kemnitz, M. Doerr, U. T. Bornscheuer, M. Delcea, M. Lammers, Nature Communications 2024,15, 6002. doi: 0.1038/s41467-024-49952-0