Sie befinden sich auf dem TYPO3-Testsystem. Dieses System ist ausschließlich für Anwendungstest und zur Entwicklung vorgesehen.
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Felix's paper on Identification of Kazal Inhibitor Scaffolds with Identical Canonical Binding Loops and Their Effects on Binding Properties is published
Inhibitor–protease pairs form one highly integrated unit, and a secondary scaffold screen after optimizing the canonical binding loop is advisable. Optimizing the binding loop supporting scaffold can increase affinity, specificity, pH resistance, and complex stability, resulting in higher potency inhibitors. This also helps transferring results obtained from animal models to clinical trials...
Felix's paper on Identification of Kazal Inhibitor Scaffolds with Identical Canonical Binding Loops and Their Effects on Binding Properties is published in Biochemistry. Congratulations Felix!